Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes

Age-dependent oocyte aneuploidy, a major cause of Down syndrome, is associated with declining sister chromatid cohesion in postnatal oocytes. Here we show that cohesion in postnatal mouse oocytes is regulated by Tex19.1. We show Tex19.1(−/−) oocytes have defects maintaining chiasmata, missegregate t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Cell Biol
Hauptverfasser: Reichmann, Judith, Dobie, Karen, Lister, Lisa M., Crichton, James H., Best, Diana, MacLennan, Marie, Read, David, Raymond, Eleanor S., Hung, Chao-Chun, Boyle, Shelagh, Shirahige, Katsuhiko, Cooke, Howard J., Herbert, Mary, Adams, Ian R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2020
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199850/
https://ncbi.nlm.nih.gov/pubmed/32232464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201702123
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge