The Chromosomal Association of the Smc5/6 Complex Depends on Cohesion and Predicts the Level of Sister Chromatid Entanglement

The cohesin complex, which is essential for sister chromatid cohesion and chromosome segregation, also inhibits resolution of sister chromatid intertwinings (SCIs) by the topoisomerase Top2. The cohesin-related Smc5/6 complex (Smc5/6) instead accumulates on chromosomes after Top2 inactivation, known...

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Main Authors: Jeppsson, Kristian, Carlborg, Kristian K., Nakato, Ryuichiro, Berta, Davide G., Lilienthal, Ingrid, Kanno, Takaharu, Lindqvist, Arne, Brink, Maartje C., Dantuma, Nico P., Katou, Yuki, Shirahige, Katsuhiko, Sjögren, Camilla
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199498/
https://ncbi.nlm.nih.gov/pubmed/25329383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004680
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