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Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes
Age-dependent oocyte aneuploidy, a major cause of Down syndrome, is associated with declining sister chromatid cohesion in postnatal oocytes. Here we show that cohesion in postnatal mouse oocytes is regulated by Tex19.1. We show Tex19.1(−/−) oocytes have defects maintaining chiasmata, missegregate t...
में बचाया:
| में प्रकाशित: | J Cell Biol |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Rockefeller University Press
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7199850/ https://ncbi.nlm.nih.gov/pubmed/32232464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201702123 |
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