Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes

Age-dependent oocyte aneuploidy, a major cause of Down syndrome, is associated with declining sister chromatid cohesion in postnatal oocytes. Here we show that cohesion in postnatal mouse oocytes is regulated by Tex19.1. We show Tex19.1(−/−) oocytes have defects maintaining chiasmata, missegregate t...

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Vydáno v:J Cell Biol
Hlavní autoři: Reichmann, Judith, Dobie, Karen, Lister, Lisa M., Crichton, James H., Best, Diana, MacLennan, Marie, Read, David, Raymond, Eleanor S., Hung, Chao-Chun, Boyle, Shelagh, Shirahige, Katsuhiko, Cooke, Howard J., Herbert, Mary, Adams, Ian R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199850/
https://ncbi.nlm.nih.gov/pubmed/32232464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201702123
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