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Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes
Age-dependent oocyte aneuploidy, a major cause of Down syndrome, is associated with declining sister chromatid cohesion in postnatal oocytes. Here we show that cohesion in postnatal mouse oocytes is regulated by Tex19.1. We show Tex19.1(−/−) oocytes have defects maintaining chiasmata, missegregate t...
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| Publié dans: | J Cell Biol |
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| Auteurs principaux: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Rockefeller University Press
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7199850/ https://ncbi.nlm.nih.gov/pubmed/32232464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201702123 |
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