The mammalian cytosolic thioredoxin reductase pathway acts via a membrane protein to reduce ER-localised proteins

Folding of proteins entering the mammalian secretory pathway requires the insertion of the correct disulfides. Disulfide formation involves both an oxidative pathway for their insertion and a reductive pathway to remove incorrectly formed disulfides. Reduction of these disulfides is crucial for corr...

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Bibliografiske detaljer
Udgivet i:J Cell Sci
Main Authors: Cao, Xiaofei, Lilla, Sergio, Cao, Zhenbo, Pringle, Marie Anne, Oka, Ojore B. V., Robinson, Philip J., Szmaja, Tomasz, van Lith, Marcel, Zanivan, Sara, Bulleid, Neil J.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197872/
https://ncbi.nlm.nih.gov/pubmed/32184267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.241976
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