Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma

Endonuclease V (EndoV) is a conserved inosine-specific ribonuclease with unknown biological function. Here, we present the first mouse model lacking EndoV, which is viable without visible abnormalities. We show that endogenous murine EndoV cleaves inosine-containing RNA in vitro, nevertheless a seri...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Kong, Xiang Yi, Vik, Erik Sebastian, Nawaz, Meh Sameen, Berges, Natalia, Dahl, Tuva Børresdatter, Vågbø, Cathrine, Suganthan, Rajikala, Segers, Filip, Holm, Sverre, Quiles-Jiménez, Ana, Gregersen, Ida, Fladeby, Cathrine, Aukrust, Pål, Bjørås, Magnar, Klungland, Arne, Halvorsen, Bente, Alseth, Ingrun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
RNA and RNA-protein complexes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192598/
https://ncbi.nlm.nih.gov/pubmed/32083667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa115
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