Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules

Endonuclease V (EndoV) is an enzyme with specificity for inosines in nucleic acids. Whereas the bacterial homologs are active on both DNA and RNA, the mammalian variants only cleave RNA, at least when assayed with recombinant proteins. Here we show that ectopically expressed, as well as endogenously...

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Publicat a:J Biol Chem
Autors principals: Nawaz, Meh Sameen, Vik, Erik Sebastian, Berges, Natalia, Fladeby, Cathrine, Bjørås, Magnar, Dalhus, Bjørn, Alseth, Ingrun
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076846/
https://ncbi.nlm.nih.gov/pubmed/27573237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.730911
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