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Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules

Endonuclease V (EndoV) is an enzyme with specificity for inosines in nucleic acids. Whereas the bacterial homologs are active on both DNA and RNA, the mammalian variants only cleave RNA, at least when assayed with recombinant proteins. Here we show that ectopically expressed, as well as endogenously...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Nawaz, Meh Sameen, Vik, Erik Sebastian, Berges, Natalia, Fladeby, Cathrine, Bjørås, Magnar, Dalhus, Bjørn, Alseth, Ingrun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076846/
https://ncbi.nlm.nih.gov/pubmed/27573237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.730911
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