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Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease

Endonuclease V (EndoV) is an enzyme with specificity for deaminated adenosine (inosine) in nucleic acids. EndoV from Escherichia coli (EcEndoV) acts both on inosines in DNA and RNA, whereas the human homolog cleaves only at inosines in RNA. Inosines in DNA are mutagenic and the role of EndoV in DNA...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Nawaz, Meh Sameen, Vik, Erik Sebastian, Ronander, Mia Elise, Solvoll, Anne Marthe, Blicher, Pernille, Bjørås, Magnar, Alseth, Ingrun, Dalhus, Bjørn
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842958/
https://ncbi.nlm.nih.gov/pubmed/27108838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24979
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