A high-throughput platform to identify small-molecule inhibitors of CRISPR-Cas9

The precise control of CRISPR-Cas9 activity is required for a number of genome engineering technologies. Here, we report a generalizable platform that provided the first synthetic small-molecule inhibitors of Streptococcus pyogenes Cas9 (SpCas9) that weigh <500 Da and are cell-permeable, reversib...

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Detaylı Bibliyografya
Yayımlandı:Cell
Asıl Yazarlar: Maji, Basudeb, Gangopadhyay, Soumyashree A., Lee, Miseon, Shi, Mengchao, Wu, Peng, Heler, Robert, Mok, Beverly, Lim, Donghyun, Siriwardena, Sachini U., Paul, Bishwajit, Dančík, Vlado, Vetere, Amedeo, Mesleh, Michael F., Marraffini, Luciano A., Liu, David R., Clemons, Paul A., Wagner, Bridget K., Choudhary, Amit
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7182439/
https://ncbi.nlm.nih.gov/pubmed/31051099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.04.009
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