A high-throughput platform to identify small-molecule inhibitors of CRISPR-Cas9

The precise control of CRISPR-Cas9 activity is required for a number of genome engineering technologies. Here, we report a generalizable platform that provided the first synthetic small-molecule inhibitors of Streptococcus pyogenes Cas9 (SpCas9) that weigh <500 Da and are cell-permeable, reversib...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Maji, Basudeb, Gangopadhyay, Soumyashree A., Lee, Miseon, Shi, Mengchao, Wu, Peng, Heler, Robert, Mok, Beverly, Lim, Donghyun, Siriwardena, Sachini U., Paul, Bishwajit, Dančík, Vlado, Vetere, Amedeo, Mesleh, Michael F., Marraffini, Luciano A., Liu, David R., Clemons, Paul A., Wagner, Bridget K., Choudhary, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7182439/
https://ncbi.nlm.nih.gov/pubmed/31051099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.04.009
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