Heterogeneous cancer associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner

Heterogeneous prostatic carcinoma associated fibroblasts (CAF) contribute to tumor progression and resistance to androgen signaling deprivation therapy (ADT). CAF subjected to extended passaging, compared to low passage CAF, were found to lose tumor expansion potential and heterogeneity. Cell surfac...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Kato, Manabu, Placencio-Hickok, Veronica R., Madhav, Anisha, Haldar, Subhash, Tripathi, Manisha, Billet, Sandrine, Mishra, Rajeev, Smith, Bethany, Rohena-Rivera, Krizia, Agarwal, Priyanka, Duong, Frank, Angara, Bryan, Hickok, David, Liu, Zhenqiu, Bhowmick, Neil A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7182071/
https://ncbi.nlm.nih.gov/pubmed/30177832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0461-3
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