Heterogeneous cancer associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner

Heterogeneous prostatic carcinoma associated fibroblasts (CAF) contribute to tumor progression and resistance to androgen signaling deprivation therapy (ADT). CAF subjected to extended passaging, compared to low passage CAF, were found to lose tumor expansion potential and heterogeneity. Cell surfac...

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Bibliographic Details
Published in:Oncogene
Main Authors: Kato, Manabu, Placencio-Hickok, Veronica R., Madhav, Anisha, Haldar, Subhash, Tripathi, Manisha, Billet, Sandrine, Mishra, Rajeev, Smith, Bethany, Rohena-Rivera, Krizia, Agarwal, Priyanka, Duong, Frank, Angara, Bryan, Hickok, David, Liu, Zhenqiu, Bhowmick, Neil A.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7182071/
https://ncbi.nlm.nih.gov/pubmed/30177832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0461-3
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