Heterogeneous cancer associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner

Heterogeneous prostatic carcinoma associated fibroblasts (CAF) contribute to tumor progression and resistance to androgen signaling deprivation therapy (ADT). CAF subjected to extended passaging, compared to low passage CAF, were found to lose tumor expansion potential and heterogeneity. Cell surfac...

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Publicado en:Oncogene
Main Authors: Kato, Manabu, Placencio-Hickok, Veronica R., Madhav, Anisha, Haldar, Subhash, Tripathi, Manisha, Billet, Sandrine, Mishra, Rajeev, Smith, Bethany, Rohena-Rivera, Krizia, Agarwal, Priyanka, Duong, Frank, Angara, Bryan, Hickok, David, Liu, Zhenqiu, Bhowmick, Neil A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7182071/
https://ncbi.nlm.nih.gov/pubmed/30177832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0461-3
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