Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance

Stromal-epithelial interactions dictate cancer progression and therapeutic response. Prostate cancer (PCa) cells were identified to secrete greater concentration of mitochondrial DNA (mtDNA) compared to noncancer epithelia. Based on the recognized coevolution of cancer-associated fibroblasts (CAF) w...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Haldar, Subhash, Mishra, Rajeev, Billet, Sandrine, Thiruvalluvan, Manish, Placencio-Hickok, Veronica R., Madhav, Anisha, Duong, Frank, Angara, Bryan, Agarwal, Priyanka, Tighiouart, Mourad, Posadas, Edwin M., Bhowmick, Neil A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165425/
https://ncbi.nlm.nih.gov/pubmed/32238563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910952117
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