Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance

Stromal-epithelial interactions dictate cancer progression and therapeutic response. Prostate cancer (PCa) cells were identified to secrete greater concentration of mitochondrial DNA (mtDNA) compared to noncancer epithelia. Based on the recognized coevolution of cancer-associated fibroblasts (CAF) w...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Haldar, Subhash, Mishra, Rajeev, Billet, Sandrine, Thiruvalluvan, Manish, Placencio-Hickok, Veronica R., Madhav, Anisha, Duong, Frank, Angara, Bryan, Agarwal, Priyanka, Tighiouart, Mourad, Posadas, Edwin M., Bhowmick, Neil A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165425/
https://ncbi.nlm.nih.gov/pubmed/32238563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910952117
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