Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance

Stromal-epithelial interactions dictate cancer progression and therapeutic response. Prostate cancer (PCa) cells were identified to secrete greater concentration of mitochondrial DNA (mtDNA) compared to noncancer epithelia. Based on the recognized coevolution of cancer-associated fibroblasts (CAF) w...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Haldar, Subhash, Mishra, Rajeev, Billet, Sandrine, Thiruvalluvan, Manish, Placencio-Hickok, Veronica R., Madhav, Anisha, Duong, Frank, Angara, Bryan, Agarwal, Priyanka, Tighiouart, Mourad, Posadas, Edwin M., Bhowmick, Neil A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165425/
https://ncbi.nlm.nih.gov/pubmed/32238563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910952117
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