EZH2 inhibition sensitizes CARM1-high, homologous recombination proficient ovarian cancers to PARP inhibition

In response to DNA double-strand breaks, MAD2L2-containing shieldin complex plays a critical role in the choice between homologous recombination (HR) and non-homologous end joining (NHEJ)-mediated repair. Here we show that EZH2 inhibition upregulates MAD2L2 and sensitizes HR-proficient epithelial ov...

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Udgivet i:Cancer Cell
Main Authors: Karakashev, Sergey, Fukumoto, Takeshi, Zhao, Bo, Lin, Jianhuang, Wu, Shuai, Fatkhutdinov, Nail, Park, Pyoung-Hwa, Semenova, Galina, Jean, Stephanie, Cadungog, Mark G., Borowsky, Mark E., Kossenkov, Andrew V., Liu, Qin, Zhang, Rugang
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7155421/
https://ncbi.nlm.nih.gov/pubmed/32004442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.12.015
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