CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity

CARM1 is an arginine methyltransferase that asymmetrically dimethylates protein substrates on arginine residues. CARM1 is often overexpressed in human cancers. However, clinically applicable cancer therapeutic strategies based on CARM1 expression remain to be explored. Here, we report that EZH2 inhi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Karakashev, Sergey, Zhu, Hengrui, Wu, Shuai, Yokoyama, Yuhki, Bitler, Benjamin G., Park, Pyoung-Hwa, Lee, Jeong-Heon, Kossenkov, Andrew V., Gaonkar, Krutika Satish, Yan, Huihuang, Drapkin, Ronny, Conejo-Garcia, Jose R., Speicher, David W., Ordog, Tamas, Zhang, Rugang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809368/
https://ncbi.nlm.nih.gov/pubmed/29434212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03031-3
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