Chargement en cours...

CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity

CARM1 is an arginine methyltransferase that asymmetrically dimethylates protein substrates on arginine residues. CARM1 is often overexpressed in human cancers. However, clinically applicable cancer therapeutic strategies based on CARM1 expression remain to be explored. Here, we report that EZH2 inhi...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Karakashev, Sergey, Zhu, Hengrui, Wu, Shuai, Yokoyama, Yuhki, Bitler, Benjamin G., Park, Pyoung-Hwa, Lee, Jeong-Heon, Kossenkov, Andrew V., Gaonkar, Krutika Satish, Yan, Huihuang, Drapkin, Ronny, Conejo-Garcia, Jose R., Speicher, David W., Ordog, Tamas, Zhang, Rugang
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809368/
https://ncbi.nlm.nih.gov/pubmed/29434212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03031-3
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!