CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity

CARM1 is an arginine methyltransferase that asymmetrically dimethylates protein substrates on arginine residues. CARM1 is often overexpressed in human cancers. However, clinically applicable cancer therapeutic strategies based on CARM1 expression remain to be explored. Here, we report that EZH2 inhi...

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Pubblicato in:Nat Commun
Autori principali: Karakashev, Sergey, Zhu, Hengrui, Wu, Shuai, Yokoyama, Yuhki, Bitler, Benjamin G., Park, Pyoung-Hwa, Lee, Jeong-Heon, Kossenkov, Andrew V., Gaonkar, Krutika Satish, Yan, Huihuang, Drapkin, Ronny, Conejo-Garcia, Jose R., Speicher, David W., Ordog, Tamas, Zhang, Rugang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809368/
https://ncbi.nlm.nih.gov/pubmed/29434212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03031-3
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