SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells

Por Wu, Shuai, Fatkhutdinov, Nail, Fukumoto, Takeshi, Bitler, Benjamin G., Park, Pyoung Hwa, Kossenkov, Andrew V., Trizzino, Marco, Tang, Hsin-Yao, Zhang, Lin, Gardini, Alessandro, Speicher, David W., Zhang, Rugang
Publicado no Nat Commun (2018)

EZH2 inhibition sensitizes CARM1-high, homologous recombination proficient ovarian cancers to PARP inhibition

Por Karakashev, Sergey, Fukumoto, Takeshi, Zhao, Bo, Lin, Jianhuang, Wu, Shuai, Fatkhutdinov, Nail, Park, Pyoung-Hwa, Semenova, Galina, Jean, Stephanie, Cadungog, Mark G., Borowsky, Mark E., Kossenkov, Andrew V., Liu, Qin, Zhang, Rugang
Publicado no Cancer Cell (2020)

CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity

Por Karakashev, Sergey, Zhu, Hengrui, Wu, Shuai, Yokoyama, Yuhki, Bitler, Benjamin G., Park, Pyoung-Hwa, Lee, Jeong-Heon, Kossenkov, Andrew V., Gaonkar, Krutika Satish, Yan, Huihuang, Drapkin, Ronny, Conejo-Garcia, Jose R., Speicher, David W., Ordog, Tamas, Zhang, Rugang
Publicado no Nat Commun (2018)

Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer

Por Fukumoto, Takeshi, Park, Pyoung Hwa, Wu, Shuai, Fatkhutdinov, Nail, Karakashev, Sergey, Nacarelli, Timothy, Kossenkov, Andrew V., Speicher, David W., Jean, Stephanie, Zhang, Lin, Wang, Tian-Li, Shih, Ie-Ming, Conejo-Garcia, Jose R., Bitler, Benjamin G., Zhang, Rugang
Publicado no Cell Rep (2018)

Amplification of the mutation-carrying BRCA2 allele promotes RAD51 loading and PARP inhibitor resistance in the absence of reversion mutations.

Por Park, Pyoung Hwa, Yamamoto, Tomomi M., Li, Hua, Alcivar, Allen L., Xia, Bing, Wang, Yifan, Bernhardy, Andrea J., Turner, Kristen M., Kossenkov, Andrew V., Watson, Zachary L., Behbakht, Kian, Casadei, Silvia, Swisher, Elizabeth M., Mischel, Paul S., Johnson, Neil, Bitler, Benjamin G.
Publicado no Mol Cancer Ther (2019)

ARID1A-mutated ovarian cancers depend on HDAC6 activity

Por Bitler, Benjamin G., Wu, Shuai, Park, Pyoung Hwa, Hai, Yang, Aird, Katherine M., Wang, Yemin, Zhai, Yali, Kossenkov, Andrew V., Vara-Ailor, Ana, Rauscher, Frank J, Zou, Weiping, Speicher, David W., Huntsman, David G., Conejo-Garcia, Jose R., Cho, Kathleen R., Christianson, David W., Zhang, Rugang
Publicado no Nat Cell Biol (2017)