Amplification of the mutation-carrying BRCA2 allele promotes RAD51 loading and PARP inhibitor resistance in the absence of reversion mutations.

Patients harboring germline Breast Cancer susceptibility genes 1 and 2 (BRCA1/2) mutations are predisposed to developing breast, pancreatic, and ovarian cancers. BRCA2 plays a critical role in homologous recombination DNA repair and deleterious mutations in BRCA2 confer sensitivity to poly(ADP-ribos...

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Detaylı Bibliyografya
Yayımlandı:Mol Cancer Ther
Asıl Yazarlar: Park, Pyoung Hwa, Yamamoto, Tomomi M., Li, Hua, Alcivar, Allen L., Xia, Bing, Wang, Yifan, Bernhardy, Andrea J., Turner, Kristen M., Kossenkov, Andrew V., Watson, Zachary L., Behbakht, Kian, Casadei, Silvia, Swisher, Elizabeth M., Mischel, Paul S., Johnson, Neil, Bitler, Benjamin G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007853/
https://ncbi.nlm.nih.gov/pubmed/31575654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0256
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