Amplification of the mutation-carrying BRCA2 allele promotes RAD51 loading and PARP inhibitor resistance in the absence of reversion mutations.

Patients harboring germline Breast Cancer susceptibility genes 1 and 2 (BRCA1/2) mutations are predisposed to developing breast, pancreatic, and ovarian cancers. BRCA2 plays a critical role in homologous recombination DNA repair and deleterious mutations in BRCA2 confer sensitivity to poly(ADP-ribos...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Park, Pyoung Hwa, Yamamoto, Tomomi M., Li, Hua, Alcivar, Allen L., Xia, Bing, Wang, Yifan, Bernhardy, Andrea J., Turner, Kristen M., Kossenkov, Andrew V., Watson, Zachary L., Behbakht, Kian, Casadei, Silvia, Swisher, Elizabeth M., Mischel, Paul S., Johnson, Neil, Bitler, Benjamin G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007853/
https://ncbi.nlm.nih.gov/pubmed/31575654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0256
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