NAMPT inhibition suppresses cancer stem-like cells associated with therapy-induced senescence in ovarian cancer

Epithelial ovarian cancer (EOC) is the most lethal of gynecologic malignancies. The standard-of-care treatment for EOC is platinum-based chemotherapy such as cisplatin. Platinum-based chemotherapy induces cellular senescence. Notably, therapy-induced senescence contributes to chemoresistance by indu...

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Vydáno v:Cancer Res
Hlavní autoři: Nacarelli, Timothy, Fukumoto, Takeshi, Zundell, Joseph A., Fatkhutdinov, Nail, Jean, Stephanie, Cadungog, Mark G., Borowsky, Mark E., Zhang, Rugang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024650/
https://ncbi.nlm.nih.gov/pubmed/31857293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-2830
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