ARIH2 is a Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection

The Cullin-RING E3 ligase (CRL) family is commonly hijacked by pathogens to redirect the host ubiquitin proteasome machinery to specific targets. During HIV infection, CRL5 is hijacked by HIV Vif to target viral restriction factors of the APOBEC3 family for ubiquitination and degradation. Here, usin...

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Publicado no:Cell Host Microbe
Main Authors: Hüttenhain, Ruth, Xu, Jiewei, Burton, Lily A., Gordon, David E., Hultquist, Judd F., Johnson, Jeffrey R., Satkamp, Laura, Hiatt, Joseph, Rhee, David Y., Baek, Kheewoong, Crosby, David C., Frankel, Alan D., Marson, Alexander, Harper, J. Wade, Alpi, Arno F., Schulman, Brenda A., Gross, John D., Krogan, Nevan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153695/
https://ncbi.nlm.nih.gov/pubmed/31253590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.05.008
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