Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors

The lentiviral protein Viral Infectivity Factor (Vif) counteracts the antiviral effects of host APOBEC3 (A3) proteins and contributes to persistent HIV infection. Vif targets A3 restriction factors for ubiquitination and proteasomal degradation by recruiting them to a multi-protein ubiquitin E3 liga...

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Udgivet i:PLoS Pathog
Main Authors: Binning, Jennifer M., Smith, Amber M., Hultquist, Judd F., Craik, Charles S., Caretta Cartozo, Nathalie, Campbell, Melody G., Burton, Lily, La Greca, Florencia, McGregor, Michael J., Ta, Hai M., Bartholomeeusen, Koen, Peterlin, B. Matija, Krogan, Nevan J., Sevillano, Natalia, Cheng, Yifan, Gross, John D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773222/
https://ncbi.nlm.nih.gov/pubmed/29304101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006830
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