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CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression
The HIV-1 accessory protein Vif hijacks a cellular cullin-RING ubiquitin ligase, CRL5, to promote degradation of the APOBEC3 family of restriction factors. Recently, the cellular transcription cofactor CBFβ was shown to form a complex with CRL5-Vif and be essential for APOBEC3 degradation and viral...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3582769/ https://ncbi.nlm.nih.gov/pubmed/23333304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.12.012 |
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