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Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration
DNA-alkylating agents are commonly used to kill cancer cells, but the base excision repair (BER) pathway they trigger can produce toxic intermediates that damage healthy tissues as well, including retinal degeneration (RD). Apoptosis, a process of programmed cell death, is assumed to be the main mec...
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| Publicado no: | Sci Signal |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7150588/ https://ncbi.nlm.nih.gov/pubmed/30755477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau9216 |
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