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Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration
DNA-alkylating agents are commonly used to kill cancer cells, but the base excision repair (BER) pathway they trigger can produce toxic intermediates that damage healthy tissues as well, including retinal degeneration (RD). Apoptosis, a process of programmed cell death, is assumed to be the main mec...
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| Опубликовано в: : | Sci Signal |
|---|---|
| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7150588/ https://ncbi.nlm.nih.gov/pubmed/30755477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau9216 |
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