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Targeting the cyclin-dependent kinase 5 in metastatic melanoma

The cyclin-dependent kinase 5 (CDK5), originally described as a neuronal-specific kinase, is also frequently activated in human cancers. Using conditional CDK5 knockout mice and a mouse model of highly metastatic melanoma, we found that CDK5 is dispensable for the growth of primary tumors. However,...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Sharma, Samanta, Zhang, Tian, Michowski, Wojciech, Rebecca, Vito W., Xiao, Min, Ferretti, Roberta, Suski, Jan M., Bronson, Roderick T., Paulo, Joao A., Frederick, Dennie, Fassl, Anne, Boland, Genevieve M., Geng, Yan, Lees, Jacqueline A., Medema, Rene H., Herlyn, Meenhard, Gygi, Steven P., Sicinski, Piotr
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7149478/
https://ncbi.nlm.nih.gov/pubmed/32193336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912617117
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