Targeting the cyclin-dependent kinase 5 in metastatic melanoma

The cyclin-dependent kinase 5 (CDK5), originally described as a neuronal-specific kinase, is also frequently activated in human cancers. Using conditional CDK5 knockout mice and a mouse model of highly metastatic melanoma, we found that CDK5 is dispensable for the growth of primary tumors. However,...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sharma, Samanta, Zhang, Tian, Michowski, Wojciech, Rebecca, Vito W., Xiao, Min, Ferretti, Roberta, Suski, Jan M., Bronson, Roderick T., Paulo, Joao A., Frederick, Dennie, Fassl, Anne, Boland, Genevieve M., Geng, Yan, Lees, Jacqueline A., Medema, Rene H., Herlyn, Meenhard, Gygi, Steven P., Sicinski, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7149478/
https://ncbi.nlm.nih.gov/pubmed/32193336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912617117
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