Targeting the cyclin-dependent kinase 5 in metastatic melanoma

The cyclin-dependent kinase 5 (CDK5), originally described as a neuronal-specific kinase, is also frequently activated in human cancers. Using conditional CDK5 knockout mice and a mouse model of highly metastatic melanoma, we found that CDK5 is dispensable for the growth of primary tumors. However,...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sharma, Samanta, Zhang, Tian, Michowski, Wojciech, Rebecca, Vito W., Xiao, Min, Ferretti, Roberta, Suski, Jan M., Bronson, Roderick T., Paulo, Joao A., Frederick, Dennie, Fassl, Anne, Boland, Genevieve M., Geng, Yan, Lees, Jacqueline A., Medema, Rene H., Herlyn, Meenhard, Gygi, Steven P., Sicinski, Piotr
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7149478/
https://ncbi.nlm.nih.gov/pubmed/32193336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912617117
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