Kinase-independent function of E-type cyclins in liver cancer

E-type cyclins (cyclins E1 and E2) are components of the core cell cycle machinery and are overexpressed in many human tumor types. E cyclins are thought to drive tumor cell proliferation by activating the cyclin-dependent kinase 2 (CDK2). The cyclin E1 gene represents the site of recurrent integrat...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Geng, Yan, Michowski, Wojciech, Chick, Joel M., Wang, Yaoyu E., Jecrois, M. Emmanuelle, Sweeney, Katharine E., Liu, Lijun, Han, Richard C., Ke, Nan, Zagozdzon, Agnieszka, Sicinska, Ewa, Bronson, Roderick T., Gygi, Steven P., Sicinski, Piotr
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798328/
https://ncbi.nlm.nih.gov/pubmed/29339491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711477115
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