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Continuous evolution of SpCas9 variants compatible with non-G PAMs
The targeting scope of Streptococcus pyogenes Cas9 (SpCas9) and its engineered variants is largely restricted to protospacer-adjacent motif (PAM) sequences containing Gs. Here, we report the evolution of three new SpCas9 variants that collectively recognize NRNH PAMs (where R = A or G and H = A, C,...
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| Izdano u: | Nat Biotechnol |
|---|---|
| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7145744/ https://ncbi.nlm.nih.gov/pubmed/32042170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0412-8 |
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