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PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

The inability of cells to adapt to increased environmental tonicity can lead to inflammatory gene expression and pathogenesis. The Rel family of transcription factors TonEBP and NF-κB p65 play critical roles in the switch from osmoadaptive homeostasis to inflammation, respectively. Here we identifie...

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發表在:eLife
Main Authors: Farabaugh, Kenneth T, Krokowski, Dawid, Guan, Bo-Jhih, Gao, Zhaofeng, Gao, Xing-Huang, Wu, Jing, Jobava, Raul, Ray, Greeshma, de Jesus, Tristan J, Bianchi, Massimiliano G, Chukwurah, Evelyn, Bussolati, Ovidio, Kilberg, Michael, Buchner, David A, Sen, Ganes C, Cotton, Calvin, McDonald, Christine, Longworth, Michelle, Ramakrishnan, Parameswaran, Hatzoglou, Maria
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145421/
https://ncbi.nlm.nih.gov/pubmed/32175843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52241
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