PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

The inability of cells to adapt to increased environmental tonicity can lead to inflammatory gene expression and pathogenesis. The Rel family of transcription factors TonEBP and NF-κB p65 play critical roles in the switch from osmoadaptive homeostasis to inflammation, respectively. Here we identifie...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:eLife
Κύριοι συγγραφείς: Farabaugh, Kenneth T, Krokowski, Dawid, Guan, Bo-Jhih, Gao, Zhaofeng, Gao, Xing-Huang, Wu, Jing, Jobava, Raul, Ray, Greeshma, de Jesus, Tristan J, Bianchi, Massimiliano G, Chukwurah, Evelyn, Bussolati, Ovidio, Kilberg, Michael, Buchner, David A, Sen, Ganes C, Cotton, Calvin, McDonald, Christine, Longworth, Michelle, Ramakrishnan, Parameswaran, Hatzoglou, Maria
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: eLife Sciences Publications, Ltd 2020
Θέματα:
Genetics and Genomics
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145421/
https://ncbi.nlm.nih.gov/pubmed/32175843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52241
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