Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress

High extracellular osmolarity results in a switch from an adaptive to an inflammatory gene expression program. We show that hyperosmotic stress activates the protein kinase R (PKR) independently of its RNA-binding domain. In turn, PKR stimulates nuclear accumulation of nuclear factor κB (NF-κB) p65...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Farabaugh, Kenneth T., Majumder, Mithu, Guan, Bo-Jhih, Jobava, Raul, Wu, Jing, Krokowski, Dawid, Gao, Xing-Huang, Schuster, Andrew, Longworth, Michelle, Chan, Edward D., Bianchi, Massimiliano, Dey, Madhusudan, Koromilas, Antonis E., Ramakrishnan, Parameswaran, Hatzoglou, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288580/
https://ncbi.nlm.nih.gov/pubmed/27920257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00521-16
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