Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment

In ovarian cancer, upregulation of the Wnt/β–catenin pathway leads to chemoresistance and correlates with T cell exclusion from the tumor microenvironment (TME). Our objectives were to validate these findings in an independent cohort of ovarian cancer subjects and determine whether inhibiting the Wn...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Goldsberry, Whitney N., Meza-Perez, Selene, Londoño, Angelina I., Katre, Ashwini A., Mott, Bryan T., Roane, Brandon M., Goel, Nidhi, Wall, Jaclyn A., Cooper, Sara J., Norian, Lyse A., Randall, Troy D., Birrer, Michael J., Arend, Rebecca C.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140065/
https://ncbi.nlm.nih.gov/pubmed/32213921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030766
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