Inhibiting WNT Ligand Production for Improved Immune Recognition in the Ovarian Tumor Microenvironment

In ovarian cancer, upregulation of the Wnt/β–catenin pathway leads to chemoresistance and correlates with T cell exclusion from the tumor microenvironment (TME). Our objectives were to validate these findings in an independent cohort of ovarian cancer subjects and determine whether inhibiting the Wn...

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Bibliografske podrobnosti
izdano v:Cancers (Basel)
Main Authors: Goldsberry, Whitney N., Meza-Perez, Selene, Londoño, Angelina I., Katre, Ashwini A., Mott, Bryan T., Roane, Brandon M., Goel, Nidhi, Wall, Jaclyn A., Cooper, Sara J., Norian, Lyse A., Randall, Troy D., Birrer, Michael J., Arend, Rebecca C.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7140065/
https://ncbi.nlm.nih.gov/pubmed/32213921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12030766
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