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Neutralization of TGF-β improves tumor immunity and reduces tumor progression in ovarian carcinoma
The immunosuppressive effects of transforming growth factor-beta (TGF-β) promotes tumor progression and diminishes response to therapy. In this study we used ID8-p53(−/−) tumors as a murine model of high grade serous ovarian cancer. A monoclonal antibody targeting all three TGF-β ligands was used to...
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| Publié dans: | Mol Cancer Ther |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7933076/ https://ncbi.nlm.nih.gov/pubmed/33323456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0412 |
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