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Neutralization of TGF-β improves tumor immunity and reduces tumor progression in ovarian carcinoma

The immunosuppressive effects of transforming growth factor-beta (TGF-β) promotes tumor progression and diminishes response to therapy. In this study we used ID8-p53(−/−) tumors as a murine model of high grade serous ovarian cancer. A monoclonal antibody targeting all three TGF-β ligands was used to...

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Detaylı Bibliyografya
Yayımlandı:Mol Cancer Ther
Asıl Yazarlar: Roane, Brandon M., Meza-Perez, Selene, Katre, Ashwini A., Goldsberry, Whitney N., Randall, Troy D., Norian, Lyse A., Birrer, Michael J., Arend, Rebecca C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933076/
https://ncbi.nlm.nih.gov/pubmed/33323456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0412
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