Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer

BACKGROUND: The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell exclusion and resistance to checkpoint inhibitors. We sought to determine whether a small molecule inhibitor of this pathway, WNT974, would impair tumor growth, affect gene expression patterns...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Ther Adv Med Oncol
Huvudupphovsmän: Doo, David W., Meza-Perez, Selene, Londoño, Angelina I., Goldsberry, Whitney N., Katre, Ashwini A., Boone, Jonathan D., Moore, Dylana J., Hudson, Cindy T., Betella, Ilaria, McCaw, Tyler R., Gangrade, Abhishek, Bao, Riyue, Luke, Jason J., Yang, Eddy S., Birrer, Michael J., Starenki, Dmytro, Cooper, Sara J., Buchsbaum, Donald J., Norian, Lyse A., Randall, Troy D., Arend, Rebecca C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: SAGE Publications 2020
Ämnen:
Immunotherapy in Gynecological Cancers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158255/
https://ncbi.nlm.nih.gov/pubmed/32313567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835920913798
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk