Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer

BACKGROUND: The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell exclusion and resistance to checkpoint inhibitors. We sought to determine whether a small molecule inhibitor of this pathway, WNT974, would impair tumor growth, affect gene expression patterns...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Ther Adv Med Oncol
Päätekijät: Doo, David W., Meza-Perez, Selene, Londoño, Angelina I., Goldsberry, Whitney N., Katre, Ashwini A., Boone, Jonathan D., Moore, Dylana J., Hudson, Cindy T., Betella, Ilaria, McCaw, Tyler R., Gangrade, Abhishek, Bao, Riyue, Luke, Jason J., Yang, Eddy S., Birrer, Michael J., Starenki, Dmytro, Cooper, Sara J., Buchsbaum, Donald J., Norian, Lyse A., Randall, Troy D., Arend, Rebecca C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: SAGE Publications 2020
Aiheet:
Immunotherapy in Gynecological Cancers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158255/
https://ncbi.nlm.nih.gov/pubmed/32313567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835920913798
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