Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer

BACKGROUND: The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell exclusion and resistance to checkpoint inhibitors. We sought to determine whether a small molecule inhibitor of this pathway, WNT974, would impair tumor growth, affect gene expression patterns...

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Pubblicato in:Ther Adv Med Oncol
Autori principali: Doo, David W., Meza-Perez, Selene, Londoño, Angelina I., Goldsberry, Whitney N., Katre, Ashwini A., Boone, Jonathan D., Moore, Dylana J., Hudson, Cindy T., Betella, Ilaria, McCaw, Tyler R., Gangrade, Abhishek, Bao, Riyue, Luke, Jason J., Yang, Eddy S., Birrer, Michael J., Starenki, Dmytro, Cooper, Sara J., Buchsbaum, Donald J., Norian, Lyse A., Randall, Troy D., Arend, Rebecca C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2020
Soggetti:
Immunotherapy in Gynecological Cancers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158255/
https://ncbi.nlm.nih.gov/pubmed/32313567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835920913798
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