Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer

BACKGROUND: The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell exclusion and resistance to checkpoint inhibitors. We sought to determine whether a small molecule inhibitor of this pathway, WNT974, would impair tumor growth, affect gene expression patterns...

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Vydáno v:Ther Adv Med Oncol
Hlavní autoři: Doo, David W., Meza-Perez, Selene, Londoño, Angelina I., Goldsberry, Whitney N., Katre, Ashwini A., Boone, Jonathan D., Moore, Dylana J., Hudson, Cindy T., Betella, Ilaria, McCaw, Tyler R., Gangrade, Abhishek, Bao, Riyue, Luke, Jason J., Yang, Eddy S., Birrer, Michael J., Starenki, Dmytro, Cooper, Sara J., Buchsbaum, Donald J., Norian, Lyse A., Randall, Troy D., Arend, Rebecca C.
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2020
Témata:
Immunotherapy in Gynecological Cancers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158255/
https://ncbi.nlm.nih.gov/pubmed/32313567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835920913798
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