Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer

BACKGROUND: The Wnt/β-catenin pathway is linked to tumorigenesis in a variety of tumors and promotes T cell exclusion and resistance to checkpoint inhibitors. We sought to determine whether a small molecule inhibitor of this pathway, WNT974, would impair tumor growth, affect gene expression patterns...

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Veröffentlicht in:Ther Adv Med Oncol
Hauptverfasser: Doo, David W., Meza-Perez, Selene, Londoño, Angelina I., Goldsberry, Whitney N., Katre, Ashwini A., Boone, Jonathan D., Moore, Dylana J., Hudson, Cindy T., Betella, Ilaria, McCaw, Tyler R., Gangrade, Abhishek, Bao, Riyue, Luke, Jason J., Yang, Eddy S., Birrer, Michael J., Starenki, Dmytro, Cooper, Sara J., Buchsbaum, Donald J., Norian, Lyse A., Randall, Troy D., Arend, Rebecca C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2020
Schlagworte:
Immunotherapy in Gynecological Cancers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158255/
https://ncbi.nlm.nih.gov/pubmed/32313567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835920913798
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