ID: 203: Middle East respiratory syndrome coronavirus accessory protein NS4b is a 2H-Phosphoesterase that degrades 2′,5′-oligoadenylate activators of RNase L

Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The interferon-inducible 2′,5′-oligoadenylate (2-5A) synthetases (OAS) and ribonuclease L (RNase L) are components of a potent host antiviral pathway. We previously showed that murine coronaviru...

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Publicado en:Cytokine
Autores principales: Jha, Babal K., Thornbrough, Joshua M., Goldstein, Stephen A., Elliott, Ruth, Weiss, Susan R., Silverman, Robert H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Science Ltd 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7129261/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2015.08.207
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