Structural Basis for 2′-5′-Oligoadenylate Binding and Enzyme Activity of a Viral RNase L Antagonist

Synthesis of 2′-5′-oligoadenylates (2-5A) by oligoadenylate synthetase (OAS) is an important innate cellular response that limits viral replication by activating the latent cellular RNase, RNase L, to degrade single-stranded RNA. Some rotaviruses and coronaviruses antagonize the OAS/RNase L pathway...

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Bibliografiske detaljer
Udgivet i:	J Virol
Main Authors:	Ogden, Kristen M., Hu, Liya, Jha, Babal K., Sankaran, Banumathi, Weiss, Susan R., Silverman, Robert H., Patton, John T., Prasad, B. V. Venkataram
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology 2015
Fag:	Structure and Assembly
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4468480/ https://ncbi.nlm.nih.gov/pubmed/25878106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00701-15
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Structural Basis for 2′-5′-Oligoadenylate Binding and Enzyme Activity of a Viral RNase L Antagonist

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