Structural Basis for 2′-5′-Oligoadenylate Binding and Enzyme Activity of a Viral RNase L Antagonist

Synthesis of 2′-5′-oligoadenylates (2-5A) by oligoadenylate synthetase (OAS) is an important innate cellular response that limits viral replication by activating the latent cellular RNase, RNase L, to degrade single-stranded RNA. Some rotaviruses and coronaviruses antagonize the OAS/RNase L pathway...

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Vydáno v:J Virol
Hlavní autoři: Ogden, Kristen M., Hu, Liya, Jha, Babal K., Sankaran, Banumathi, Weiss, Susan R., Silverman, Robert H., Patton, John T., Prasad, B. V. Venkataram
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Structure and Assembly
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468480/
https://ncbi.nlm.nih.gov/pubmed/25878106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00701-15
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