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Cell-Type-Specific Effects of RNase L on Viral Induction of Beta Interferon
The interferon (IFN)-inducible antiviral state is mediated in part by the 2′,5′-oligoadenylate (2-5A) synthetase (OAS)/RNase L system. 2-5A, produced from ATP by OAS proteins in response to viral double-stranded RNA, binds to and activates RNase L. RNase L restricts viral infections by degrading vir...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Microbiology
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3940032/ https://ncbi.nlm.nih.gov/pubmed/24570368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00856-14 |
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