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RNase L Activates the NLRP3 Inflammasome During Viral Infections

The NLRP3 inflammasome assembles in response to danger signals, triggering self-cleavage of procaspase-1 and production of the proinflammatory cytokine IL-1β. Although virus infection activates the NLRP3 inflammasome, the underlying events remain incompletely understood. We report that virus activat...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Chakrabarti, Arindam, Banerjee, Shuvojit, Franchi, Luigi, Loo, Yueh-Ming, Gale, Michael, Núñez, Gabriel, Silverman, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393362/
https://ncbi.nlm.nih.gov/pubmed/25816776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.02.010
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