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TNF-α Mediate Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

The Nlrp3 inflammasome is critical for the activation of caspase-1 in response to danger signals and particulate matter. However, its role in sterile inflammation remains unclear because pre-stimulation of phagocytic cells with microbial molecules is required for caspase-1 activation. We show here t...

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Detalhes bibliográficos
Main Authors: Franchi, Luigi, Eigenbrod, Tatjana, Núñez, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754237/
https://ncbi.nlm.nih.gov/pubmed/19542372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900173
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