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The Inflammasome: A Caspase-1 Activation Platform Regulating Immune Responses and Disease Pathogenesis
The inflammasome is a multi-protein complex that mediates activation of caspase-1 which promotes the secretion of the proinflammatory cytokines IL-1β and IL-18 as well as pyroptosis, a form of cell death induced by bacterial pathogens. Members of the Nod-like receptor family including NLRP1, NLRP3 a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2820724/ https://ncbi.nlm.nih.gov/pubmed/19221555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1703 |
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