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A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome
The mechanism by which bacterial pathogens activate caspase-1 via Nlrp3 remains poorly understood. Here we show that the ability of Staphylococcus aureus, a leading cause of infection in humans, to activate caspase-1 and induce IL-1β secretion resides in culture supernatants of growing bacteria. Cas...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2762867/ https://ncbi.nlm.nih.gov/pubmed/19717510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900729 |
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