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A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome

The mechanism by which bacterial pathogens activate caspase-1 via Nlrp3 remains poorly understood. Here we show that the ability of Staphylococcus aureus, a leading cause of infection in humans, to activate caspase-1 and induce IL-1β secretion resides in culture supernatants of growing bacteria. Cas...

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Main Authors: Muñoz-Planillo, Raúl, Franchi, Luigi, Miller, Lloyd S., Núñez, Gabriel
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762867/
https://ncbi.nlm.nih.gov/pubmed/19717510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900729
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