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The NLRP3 Inflammasome is Critical for Alum-Mediated IL-1β Secretion but Dispensable for Adjuvant Activity
Alum (aluminiun hydroxide) is the most widely used adjuvant in human vaccines, but the immune mechanisms that are activated by alum remain poorly understood. Alum has been recently shown to promote caspase-1 activation and IL-1β secretion but the cellular pathways involved remain elusive. Here we re...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2759997/ https://ncbi.nlm.nih.gov/pubmed/18624356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838549 |
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