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The NLRP3 Inflammasome is Critical for Alum-Mediated IL-1β Secretion but Dispensable for Adjuvant Activity

Alum (aluminiun hydroxide) is the most widely used adjuvant in human vaccines, but the immune mechanisms that are activated by alum remain poorly understood. Alum has been recently shown to promote caspase-1 activation and IL-1β secretion but the cellular pathways involved remain elusive. Here we re...

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Main Authors: Franchi, Luigi, Núñez, Gabriel
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759997/
https://ncbi.nlm.nih.gov/pubmed/18624356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838549
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