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The Protein Kinase PKR is Critical for LPS-induced iNOS Production, but Dispensable for Inflammasome Activation in Macrophages

The inflammasomes are multi-protein platforms that drive the activation of caspase-1 leading to the processing and secretion of biologically active IL-1β and IL-18. Different inflammasomes including NLRP3, NLRC4 and AIM2 are activated and assembled in response to distinct microbial or endogenous sti...

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Autors principals: He, Yuan, Franchi, Luigi, Núñez, Gabriel
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757543/
https://ncbi.nlm.nih.gov/pubmed/23401008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201243187
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