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Mechanism of Impaired NLRP3 Inflammasome Priming by Monophosphoryl Lipid A
Monophosphoryl lipid A (MLA), a nontoxic derivative of the endotoxin lipopolysaccharide (LPS), has been approved in the United States for use as a vaccine adjuvant. LPS and MLA are ligands of Toll-like receptor 4 (TLR4), and it has been unclear why LPS triggers toxic inflammation, whereas MLA genera...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3249414/ https://ncbi.nlm.nih.gov/pubmed/21540455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001486 |
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